Pharmacology


Recent Pharmacology News

Induction of CYP2C19 and CYP3A Activity Following Repeated Administration of Efavirenz in Healthy Volunteers

Induction of CYP2C19 and CYP3A Activity Following Repeated Administration of Efavirenz in Healthy Volunteers Clinical Pharmacology & Therapeutics advance online publication, February 8, 2012. doi:10.1038/clpt.2011.249 Authors: V Michaud, E Ogburn, N Thong, A O Aregbe, T C Quigg, D A Flock... (original story)

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Adaptive Licensing: Taking the Next Step in the Evolution of Drug Approval

Adaptive Licensing: Taking the Next Step in the Evolution of Drug Approval Clinical Pharmacology & Therapeutics advance online publication, February 15, 2012. doi:10.1038/clpt.2011.345 Authors: H-G Eichler, K Oye, L G Baird, E Abadie, J Brown, C L Drum, J Ferguson, S Garner, P Honig, M Hu... (original story)

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Prediction of Weight Loss and Regain Following Dietary, Lifestyle, and Pharmacologic Intervention

Prediction of Weight Loss and Regain Following Dietary, Lifestyle, and Pharmacologic Intervention Clinical Pharmacology & Therapeutics advance online publication, February 15, 2012. doi:10.1038/clpt.2011.333 Authors: A Napolitano, S R Miller, P R Murgatroyd, B Delafont, A Brooke, M Elkhaw... (original story)

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A Randomized, Placebo-Controlled Study of the Effects of Telcagepant on Exercise Time in Patients With Stable Angina

A Randomized, Placebo-Controlled Study of the Effects of Telcagepant on Exercise Time in Patients With Stable Angina Clinical Pharmacology & Therapeutics advance online publication, January 25, 2012. doi:10.1038/clpt.2011.246 Authors: B R Chaitman, A P Ho, M O Behm, J F Rowe, J S Palcza, ... (original story)

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Shift From Surrogate End Point to Outcome Trials: Implications for Cardiovascular Safety Assessment in Development Programs for Antidiabetic Drugs

Shift From Surrogate End Point to Outcome Trials: Implications for Cardiovascular Safety Assessment in Development Programs for Antidiabetic Drugs Clinical Pharmacology & Therapeutics advance online publication, November 23, 2011. doi:10.1038/clpt.2011.257 Authors: J F Marcinak, P Viswana... (original story)

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Oral Flurbiprofen Metabolic Ratio Assessment Using a Single-Point Dried Blood Spot

Oral Flurbiprofen Metabolic Ratio Assessment Using a Single-Point Dried Blood Spot Clinical Pharmacology & Therapeutics advance online publication, January 11, 2012. doi:10.1038/clpt.2011.247 Authors: Y Daali, C Samer, J Déglon, A Thomas, J Chabert, M Rebsamen, C Staub, P Dayer ... (original story)

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Population Pharmacokinetics and Pharmacodynamics of Piperaquine in Children With Uncomplicated Falciparum Malaria

Population Pharmacokinetics and Pharmacodynamics of Piperaquine in Children With Uncomplicated Falciparum Malaria Clinical Pharmacology & Therapeutics advance online publication, January 18, 2012. doi:10.1038/clpt.2011.254 Authors: J Tarning, I Zongo, F A Somé, N Rouamba, S Parikh, P... (original story)

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High-Dose Ibuprofen for Patent Ductus Arteriosus in Extremely Preterm Infants: A Randomized Controlled Study

High-Dose Ibuprofen for Patent Ductus Arteriosus in Extremely Preterm Infants: A Randomized Controlled Study Clinical Pharmacology & Therapeutics advance online publication, November 16, 2011. doi:10.1038/clpt.2011.284 Authors: C Dani, V Vangi, G Bertini, S Pratesi, I Lori, F Favelli, R C... (original story)

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Detection of Adverse Drug Reaction Signals Using an Electronic Health Records Database: Comparison of the Laboratory Extreme Abnormality Ratio (CLEAR) Algorithm

Detection of Adverse Drug Reaction Signals Using an Electronic Health Records Database: Comparison of the Laboratory Extreme Abnormality Ratio (CLEAR) Algorithm Clinical Pharmacology & Therapeutics advance online publication, January 11, 2012. doi:10.1038/clpt.2011.248 Authors: D Yoon, M ... (original story)

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