Pharmacology


Recent Pharmacology News

Compartment-Specific Gene Regulation of the CAR Inducer Efavirenz In Vivo

Compartment-Specific Gene Regulation of the CAR Inducer Efavirenz In Vivo Clinical Pharmacology & Therapeutics advance online publication, May 16, 2012. doi:10.1038/clpt.2012.34 Authors: H E Meyer zu Schwabedissen, S Oswald, C Bresser, A Nassif, C Modess, Z Desta, E T Ogburn, M Marinova, ... (original story)

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Antidepressant Use and Risk of Out-of-Hospital Cardiac Arrest: A Nationwide Case–Time–Control Study

Antidepressant Use and Risk of Out-of-Hospital Cardiac Arrest: A Nationwide Case–Time–Control Study Clinical Pharmacology & Therapeutics advance online publication, May 16, 2012. doi:10.1038/clpt.2011.368 Authors: P Weeke, A Jensen, F Folke, G H Gislason, J B Olesen, C Anderss... (original story)

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The Clinical Pharmacogenomics Implementation Consortium: CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy

The Clinical Pharmacogenomics Implementation Consortium: CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy Clinical Pharmacology & Therapeutics advance online publication, May 23, 2012. doi:10.1038/clpt.2012.57 Authors: R A Wilke, L B Ramsey, S G Johnson, W D Maxwell, H L McLeod... (original story)

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Effects of CYP Induction by Rifampicin on Tamoxifen Exposure

Effects of CYP Induction by Rifampicin on Tamoxifen Exposure Clinical Pharmacology & Therapeutics advance online publication, May 23, 2012. doi:10.1038/clpt.2011.372 Authors: L Binkhorst, T van Gelder, W J Loos, F E de Jongh, P Hamberg, I M Ghobadi Moghaddam-Helmantel, E de Jonge, A Jager... (original story)

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Impact of the β1-Adrenoceptor Arg389Gly Polymorphism on Heart-Rate Responses to Bisoprolol and Carvedilol in Heart-Failure Patients

Impact of the β1-Adrenoceptor Arg389Gly Polymorphism on Heart-Rate Responses to Bisoprolol and Carvedilol in Heart-Failure Patients Clinical Pharmacology & Therapeutics advance online publication, May 23, 2012. doi:10.1038/clpt.2012.18 Authors: T Rau, H-D Düngen, F Edelmann, F W... (original story)

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Active Safety Monitoring of Newly Marketed Medications in a Distributed Data Network: Application of a Semi-Automated Monitoring System

Active Safety Monitoring of Newly Marketed Medications in a Distributed Data Network: Application of a Semi-Automated Monitoring System Clinical Pharmacology & Therapeutics advance online publication, May 16, 2012. doi:10.1038/clpt.2011.369 Authors: J J Gagne, R J Glynn, J A Rassen, A M W... (original story)

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Operational Implementation of Prospective Genotyping for Personalized Medicine: The Design of the Vanderbilt PREDICT Project

Operational Implementation of Prospective Genotyping for Personalized Medicine: The Design of the Vanderbilt PREDICT Project Clinical Pharmacology & Therapeutics advance online publication, May 16, 2012. doi:10.1038/clpt.2011.371 Authors: J M Pulley, J C Denny, J F Peterson, G R Bernard, ... (original story)

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PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo

PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo Clinical Pharmacology & Therapeutics advance online publication, April 18, 2012. doi:10.1038/clpt.2011.336 Authors: Kathrin Klein, Maria Thomas, Stefan Winter, Andreas K. Nussler, Mikko Niemi, Matthias Schwab ... (original story)

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Sildenafil Increases Digital Skin Blood Flow During All Phases of Local Cooling in Primary Raynaud's Phenomenon

Sildenafil Increases Digital Skin Blood Flow During All Phases of Local Cooling in Primary Raynaud's Phenomenon Clinical Pharmacology & Therapeutics advance online publication, March 28, 2012. doi:10.1038/clpt.2011.302 Authors: M Roustit, M Hellmann, C Cracowski, S Blaise ... (original story)

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Human Pregnane X Receptor Genotype of the Donor but Not of the Recipient Is a Risk Factor for Delayed Graft Function After Renal Transplantation

Human Pregnane X Receptor Genotype of the Donor but Not of the Recipient Is a Risk Factor for Delayed Graft Function After Renal Transplantation Clinical Pharmacology & Therapeutics advance online publication, March 28, 2012. doi:10.1038/clpt.2011.346 Authors: I A Hauser, S Kruck, S Gauer... (original story)

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