Pharmacology


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Joint Modeling of Efficacy, Dropout, and Tolerability in Flexible-Dose Trials: A Case Study in Depression

Joint Modeling of Efficacy, Dropout, and Tolerability in Flexible-Dose Trials: A Case Study in Depression Clinical Pharmacology & Therapeutics advance online publication, April 4, 2012. doi:10.1038/clpt.2011.322 Authors: A Russu, E Marostica, G De Nicolao, A C Hooker, I Poggesi, R Gomeni ... (original story)

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PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo

PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo Clinical Pharmacology & Therapeutics advance online publication, April 18, 2012. doi:10.1038/clpt.2011.336 Authors: Kathrin Klein, Maria Thomas, Stefan Winter, Andreas K. Nussler, Mikko Niemi, Matthias Schwab ... (original story)

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Sildenafil Increases Digital Skin Blood Flow During All Phases of Local Cooling in Primary Raynaud's Phenomenon

Sildenafil Increases Digital Skin Blood Flow During All Phases of Local Cooling in Primary Raynaud's Phenomenon Clinical Pharmacology & Therapeutics advance online publication, March 28, 2012. doi:10.1038/clpt.2011.302 Authors: M Roustit, M Hellmann, C Cracowski, S Blaise ... (original story)

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Human Pregnane X Receptor Genotype of the Donor but Not of the Recipient Is a Risk Factor for Delayed Graft Function After Renal Transplantation

Human Pregnane X Receptor Genotype of the Donor but Not of the Recipient Is a Risk Factor for Delayed Graft Function After Renal Transplantation Clinical Pharmacology & Therapeutics advance online publication, March 28, 2012. doi:10.1038/clpt.2011.346 Authors: I A Hauser, S Kruck, S Gauer... (original story)

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A Screening Study of Drug–Drug Interactions in Cerivastatin Users: An Adverse Effect of Clopidogrel

A Screening Study of Drug–Drug Interactions in Cerivastatin Users: An Adverse Effect of Clopidogrel Clinical Pharmacology & Therapeutics advance online publication, March 14, 2012. doi:10.1038/clpt.2011.295 Authors: J S Floyd, R Kaspera, K D Marciante, N S Weiss, S R Heckbert, T Lum... (original story)

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Steady-State Carbamazepine Pharmacokinetics Following Oral and Stable-Labeled Intravenous Administration in Epilepsy Patients: Effects of Race and Sex

Steady-State Carbamazepine Pharmacokinetics Following Oral and Stable-Labeled Intravenous Administration in Epilepsy Patients: Effects of Race and Sex Clinical Pharmacology & Therapeutics advance online publication, January 25, 2012. doi:10.1038/clpt.2011.251 Authors: S E Marino, A K Birn... (original story)

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Comparative Impact on Prostanoid Biosynthesis of Celecoxib and the Novel Nonsteroidal Anti-Inflammatory Drug CG100649

Comparative Impact on Prostanoid Biosynthesis of Celecoxib and the Novel Nonsteroidal Anti-Inflammatory Drug CG100649 Clinical Pharmacology & Therapeutics advance online publication, January 25, 2012. doi:10.1038/clpt.2012.3 Authors: C Skarke, N Alamuddin, J A Lawson, L Cen, K J Propert ... (original story)

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Predicting Drug Interaction Potential With a Physiologically Based Pharmacokinetic Model: A Case Study of Telithromycin, a Time-Dependent CYP3A Inhibitor

Predicting Drug Interaction Potential With a Physiologically Based Pharmacokinetic Model: A Case Study of Telithromycin, a Time-Dependent CYP3A Inhibitor Clinical Pharmacology & Therapeutics advance online publication, March 7, 2012. doi:10.1038/clpt.2011.305 Authors: MdLT Vieira, P Zhao,... (original story)

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Anti-TNF Monoclonal Antibodies in Inflammatory Bowel Disease: Pharmacokinetics-Based Dosing Paradigms

Anti-TNF Monoclonal Antibodies in Inflammatory Bowel Disease: Pharmacokinetics-Based Dosing Paradigms Clinical Pharmacology & Therapeutics advance online publication, February 22, 2012. doi:10.1038/clpt.2011.328 Authors: Ingrid Ordás, Diane R. Mould, Brian G. Feagan ... (original story)

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Induction of CYP2C19 and CYP3A Activity Following Repeated Administration of Efavirenz in Healthy Volunteers

Induction of CYP2C19 and CYP3A Activity Following Repeated Administration of Efavirenz in Healthy Volunteers Clinical Pharmacology & Therapeutics advance online publication, February 8, 2012. doi:10.1038/clpt.2011.249 Authors: V Michaud, E Ogburn, N Thong, A O Aregbe, T C Quigg, D A Flock... (original story)

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